姓    名：何一燕

职    称：教授

电子邮箱：yiyanhe@njtech.edu.cn

办公地点：润德楼(材料学科楼)B503、丁家桥科创大楼A605

学缘与工作经历

2025.10-11，西班牙巴斯克大学，访问学者

2023-至今，南京工业大学，教授

2020-2026，南京工业大学，高分子系副主任、院长助理

2018-2019，新加坡科技研究局生物工程与纳米技术研究院，访问学者

2017-2022，南京工业大学，副教授

2014-2017，四川大学国家生物医学材料工程技术研究中心，讲师

2009-2014，四川大学国家生物医学材料工程技术研究中心，博士

2005-2009，四川大学化学学院，本科

教学与科研简介

承担《高分子材料》、《人工智能与高分子材料》、《AI探秘化学与材料》等本科生课程和《生物材料》等研究生课程的教学工作。获校青年教师授课竞赛一等奖、校微课教学比赛特等奖等，并入选校本科在线教学优秀案例。近5年指导本科毕业设计（论文）48篇，获校优秀9篇、省优秀1篇，多次获评优秀指导教师。指导大创项目20项，其中国家级5项、省级5项，获本科生学术科技论坛优秀作品奖特等奖2项及优秀指导教师一等奖。培养研究生22名，在读11名（含两名伊朗、巴基斯坦籍博士生），2人获校优秀硕士学位论文，2人获校三好研究生，1人获批教育部产学合作协同育人项目，3人获批江苏省研究生科研与实践创新计划，1人赴德国攻博，2人分别赴西班牙、俄罗斯联培。

主要从事生物医用水凝胶（用于创面修复、医用组织粘合、药物递送）、智能药物递送载体材料、聚合物功能涂层（防雾、防污、润滑等）以及AI赋能生物医用材料方面的研究。主持国自然面上项目2项、国自然青年基金、国家重点研发计划项目子课题、教育部产学合作协同育人项目等项目。在Advanced Materials、Biomaterials、ACS Nano和Advanced Healthcare Materials等高水平期刊上发表论文50余篇，授权美国发明专利1件、欧洲发明专利1件、中国发明专利10余件。担任《中国材料进展》、《Materials》期刊青年编委。

高水平代表性论文（近5年）

Zhuohao Gu, Jiafeng Wang, Xinglei Shi, Yin Zhou, Yanming Chen, Yiyan He*, Lihuang Wu*, Yuwen Cui*, Zhongwei Gu. Dynamic Boronate Ester Crosslinked Hyaluronic Acid Hydrogel Patch Enabling Fast Dissolution and Rapid Oral Mucosal Delivery of Amorphous Sumatriptan. Carbohydrate Polymers 2026, 375, 124751.

Danying Yi†, Tao Wang†, Shuangshuang Xu, Yuying Liu, Zhonghao Wang, Ning Li, Ye Wu*, Yiyan He*, Injectable ROS/pH-Responsive Hydrogel for Synergistic Chemo-Photodynamic Tumor Therapy and Enhanced Wound Healing. Advanced Healthcare Materials 2026, e02349.

Bincan Deng, Fernando López Lasaosa, Dingding Chen, Caimiao Zheng, Yiyan He*, Chen Xuan, Yuwen Cui*, Manuel Doblaré*. An interactive Bayesian optimization framework for intelligent design of HAMA/GelMA hybrid hydrogels. Polymer Testing 2026, 156, 109132.

Yin Zhou, Yutong Chen, Wentao Zhao, Jiafeng Wang, Yi Chen, Haobo Wen, Yiyan He*, Ning Li*, Hongli Mao, Yuwen Cui*, Zhongwei Gu. Nanoflower Mediated Gallium Protoporphyrin IX Complex for Intracellular Antibacterial and Immunomodulatory Effects in Macrophage Targeted Therapy. ACS Nano 2025, 19, 26, 23659–23679.

Huiwen Xue†, Danying Yi†, Jiayi Wang, Zijie Li, Yuhang Jiang, Shengnan Ma*, Wanjia Peng*, Yiyan He*, Hongli Mao, Zhongwei Gu. Rapid Gelation of Anti Swelling, Self-Healing, and Biocompatible PEG Hydrogels Based on CBT Cys Click Reaction under Mild Conditions. ACS Macro Letters 2025, 14(5):664–670.

Jiliang Song, Fengyu Dai, Yanming Chen, Zhuohao Gu, Yi Chen, Yin Zhou, Wanjia Peng, Peiyong Liu*, Yiyan He*, Zhongwei Gu, Lian Zhou*, Engineering innovative Pullulan-Hyaluronan water-soluble packaging films for fast-disintegrating hard capsules. Chemical Engineering Journal 2025, 505, 159773.

Lihuang Wu, Yuqi Wang, Xinyue Zhao, Tingting Zhao, Junhua Li, Yi Kuang, Yiyan He*, Shengxiang Yang*, Zhongwei Gu, Hongli Mao*. A self-adhesive hierarchical nanofiber patch for dynamic and multistage management of full-thickness cutaneous wounds. Journal of Nanobiotechnology 2025, 23, 448.

Bincan Deng, Fernando López Lasaosa, Dingding Chen, Yiyan He*, Chen Xuan, Yuwen Cui*, Manuel Doblaré*, Transfer learning-enabled viscosity prediction for HAMA/GelMA hybrid hydrogels, Materials Today Communications 2025, 47, 113018.

Yin Zhou†, Yueyu Ma†, Abdus Samad, Zhonghao Wang, Zhuohao Gu, Jingwei Shi, Yuwen Cui*, Yiyan He*, Zhongwei Gu. Effects of irradiation sterilization on the physicochemical and functional properties of commercial biomedical hydrogels. Biomaterials Science 2025, 13, 6270-6284.

Fernando López Lasaosa, Yin Zhou, Jiliang Song, Yiyan He*, Yuwen Cui*, Rosa María Bolea Bailo, Zhongwei Gu*. Nature-Inspired Scarless Healing: Guiding Biomaterials Design for Advanced Therapies. Tissue Engineering -Part B: Reviews 2024, 30(3):371-384.

Jingjing Wei, Yin Zhou, Yiyan He*, Wentao Zhao, Zhiqiang Luo, Jian Yang*, Hongli Mao*, Zhongwei Gu, Customizing biomimetic surface attributes of dendritic lipopeptide nanoplatforms for extended circulation. Nanomedicine: Nanotechnology, Biology, and Medicine 2024, 56, 102726.

Ming Yuan, Shuangshuang Xu, Yin Zhou, Yi Chen, Jiliang Song, Shengnan Ma, Yiyan He*, Hongli Mao, Deling Kong, Zhongwei Gu. A facile bioorthogonal chemistry-based reversible to irreversible strategy to surmount the dilemma between injectability and stability of hyaluronic acid hydrogels. Carbohydrate Polymers 2023, 317, 121103.

Yuhang Jiang, Wentao Zhao, Shuangshuang Xu, Jingjing Wei, Fernando López Lasaosa, Yiyan He*, Hongli Mao, Rosa María Bolea Bailo, Deling Kong, Zhongwei Gu*. Bioinspired design of mannose-decorated globular lysine dendrimers promotes diabetic wound healing by orchestrating appropriate macrophage polarization. Biomaterials 2022, 280, 121323.

Jiajun Qin, Ming Li, Ming Yuan, Xinglei Shi, Jiliang Song, Yiyan He*, Hongli Mao, Deling Kong, and Zhongwei Gu*. Gallium(III)-Mediated Dual-Cross-Linked Alginate Hydrogels with Antibacterial Properties for Promoting Infected Wound Healing. ACS Applied Materials & Interfaces 2022, 14(19): 22426-22442.

Ming Li, Xinglei Shi, Bo Yang, Jiajun Qin, Xiaobao Han, Wanjia Peng, Yiyan He*, Hongli Mao, Deling Kong, Zhongwei Gu*. Single-component hyaluronic acid hydrogel adhesive based on phenylboronic ester bonds for hemostasis and wound closure. Carbohydrate Polymers 2022, 296, 119953.

授权发明专利（近5年）

一种具备高效内涵体逃逸的脂质化合物及其应用。专利号：ZL202411950971.2

贻贝仿生粘合剂、制备方法及其应用。专利号：ZL202311587278.9

高容量负载药物的多重响应性水凝胶及其制备方法、应用。专利号：ZL202310186166.6

一种兼具抗菌性、粘附性、自愈性和高透明度的水凝胶及其制备方法与应用。专利号：ZL202210983358.5

普鲁兰多糖止血海绵及其制备方法、应用。专利号：ZL2023115872806

苯基硼酸类化合物修饰的天然高分子在制备植物空心胶囊中的用途。专利号：ZL202310704870.6

代餐凝胶及其制备方法、应用。专利号：ZL202311587284.4

海藻酸镓微球及其制备方法、应用、药物载体。专利号：ZL202311587282.5

医用水凝胶的制备方法、水凝胶及敷料。专利号：ZL202110348693.3

Reduction stimulus-responsive gene delivery system and preparation and application thereof。美国专利号：US9707303B2